Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Dec;53(12):890-2.
doi: 10.1136/jcp.53.12.890.

Recommendations for HER2 testing in the UK

I O Ellis  1 , M Dowsett, J Bartlett, R Walker, T Cooke, W Gullick, B Gusterson, E Mallon, P B Lee
Affiliations

Recommendations for HER2 testing in the UK

I O Ellis et al. J Clin Pathol. 2000 Dec.

Abstract

Determining the HER2 status of breast carcinomas is a prerequisite for the use of the monoclonal antibody trastuzumab (Herceptin), which has recently been licensed for the treatment of metastatic disease. This necessitates a test based on archival material. The preferred analyses are immunohistochemistry with fluorescent in situ hybridisation (FISH) as a follow up test for ambiguous results. Guidelines have been developed for standardised, well controlled procedures for the provision of reliable results. A group of three reference laboratories has been established to provide advice, quality assurance, and materials, where needed.

PubMed Disclaimer

References

    1. Cancer Res. 1994 May 15;54(10):2771-7 - PubMed
    1. J Clin Pathol. 2000 May;53(5):374-81 - PubMed
    1. Breast. 2000 Jun;9(3):130-3 - PubMed