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Comparative Study
. 2001 Feb;49(1):41-6.
doi: 10.1016/s0369-8114(00)00012-2.

[Transient electrical birefringence study of the interaction between DNA and platinum compounds: cis-DDP, trans-DDP and TDP]

[Article in French]
G Mallet  1 , D Vasilescu
Affiliations
Comparative Study

[Transient electrical birefringence study of the interaction between DNA and platinum compounds: cis-DDP, trans-DDP and TDP]

[Article in French]
G Mallet et al. Pathol Biol (Paris). 2001 Feb.

Abstract

The interaction between DNA and the platinum compounds cis-DDP, trans-DDP and TDP has been studied in aqueous solution at pH 7.0 by transient electric birefringence (TEB). Data was obtained on the electro-optical characteristics and hydrodynamic properties of these solutions. The specific interactions between each of the three platinum compounds and DNA were differentiated, and their binding affinity for DNA phosphate sites was as follows, in decreasing order of importance: TDP >> cis-DDP > trans-DDP.

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