Review
doi: 10.1038/35056572.
Antigen processing by the proteasome
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- PMID: 11265247
- DOI: 10.1038/35056572
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Review
Antigen processing by the proteasome
Nat Rev Mol Cell Biol.
2001 Mar.
Abstract
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?
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