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Review
. 2001 Mar;2(3):179-87.
doi: 10.1038/35056572.

Antigen processing by the proteasome

P M Kloetzel  1
Affiliations
Review

Antigen processing by the proteasome

P M Kloetzel. Nat Rev Mol Cell Biol. 2001 Mar.

Abstract

The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?

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