Review
doi: 10.1038/35056591.
SUMO, ubiquitin's mysterious cousin
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- PMID: 11265250
- DOI: 10.1038/35056591
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Review
SUMO, ubiquitin's mysterious cousin
Nat Rev Mol Cell Biol.
2001 Mar.
Abstract
Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression. But, in contrast to ubiquitylation, sumoylation does not tag proteins for degradation, but seems to enhance their stability or modulate their subcellular compartmentalization.
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