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Review
. 2001 Mar;2(3):202-10.
doi: 10.1038/35056591.

SUMO, ubiquitin's mysterious cousin

S Müller  1 , C Hoege, G Pyrowolakis, S Jentsch
Affiliations
Review

SUMO, ubiquitin's mysterious cousin

S Müller et al. Nat Rev Mol Cell Biol. 2001 Mar.

Abstract

Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression. But, in contrast to ubiquitylation, sumoylation does not tag proteins for degradation, but seems to enhance their stability or modulate their subcellular compartmentalization.

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