This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2000 Aug;1(2):120-1.

doi: 10.1093/embo-reports/kvd035.

Creating a transloxation. Engineering interchromosomal translocations in the mouse

G Testa¹, A F Stewart

Affiliations

PMID: 11265749
PMCID: PMC1084267
DOI: 10.1093/embo-reports/kvd035

Comment

Creating a transloxation. Engineering interchromosomal translocations in the mouse

G Testa et al. EMBO Rep. 2000 Aug.

. 2000 Aug;1(2):120-1.

doi: 10.1093/embo-reports/kvd035.

Authors

G Testa¹, A F Stewart

Affiliation

¹ Gene Expression Programme, Heidelberg, Germany.

PMID: 11265749
PMCID: PMC1084267
DOI: 10.1093/embo-reports/kvd035

No abstract available

PubMed Disclaimer

Figures

None — Fig. 1. (A) According to the chromosome territory model, during interphase each chromosome resides in a unique region within the nucleus, thus separating the two LoxP sites into different chromosomal territories (colored sectors). (B) During chromosomal resortment at mitotic metaphase, the two LoxP sites can stochastically come in close contact for Cre-mediated translocation to occur.

See this image and copyright information in PMC

Comment on

Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.
Collins EC, Pannell R, Simpson EM, Forster A, Rabbitts TH. Collins EC, et al. EMBO Rep. 2000 Aug;1(2):127-32. doi: 10.1093/embo-reports/kvd021. EMBO Rep. 2000. PMID: 11265751 Free PMC article.
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.
Buchholz F, Refaeli Y, Trumpp A, Bishop JM. Buchholz F, et al. EMBO Rep. 2000 Aug;1(2):133-9. doi: 10.1093/embo-reports/kvd027. EMBO Rep. 2000. PMID: 11265752 Free PMC article.

Similar articles

Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.
Buchholz F, Refaeli Y, Trumpp A, Bishop JM. Buchholz F, et al. EMBO Rep. 2000 Aug;1(2):133-9. doi: 10.1093/embo-reports/kvd027. EMBO Rep. 2000. PMID: 11265752 Free PMC article.
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.
Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR. Higuchi M, et al. Cancer Cell. 2002 Feb;1(1):63-74. doi: 10.1016/s1535-6108(02)00016-8. Cancer Cell. 2002. PMID: 12086889
Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO.
Hiebert SW, Downing JR, Lenny N, Meyers S. Hiebert SW, et al. Curr Top Microbiol Immunol. 1996;211:253-8. doi: 10.1007/978-3-642-85232-9_25. Curr Top Microbiol Immunol. 1996. PMID: 8585956 Review. No abstract available.
Role of nuclear receptor corepressors in leukemogenesis.
Guidez F, Zelent A. Guidez F, et al. Curr Top Microbiol Immunol. 2001;254:165-85. doi: 10.1007/978-3-662-10595-5_9. Curr Top Microbiol Immunol. 2001. PMID: 11190573 Review. No abstract available.
Molecular targeting of aberrant transcription factors in leukemia: strategies for RUNX1/ETO.
Wichmann C, Grez M, Lausen J. Wichmann C, et al. Curr Drug Targets. 2010 Sep;11(9):1181-91. doi: 10.2174/138945010792006744. Curr Drug Targets. 2010. PMID: 20583973 Review.

See all similar articles

Cited by

Unmodified Cre recombinase crosses the membrane.
Will E, Klump H, Heffner N, Schwieger M, Schiedlmeier B, Ostertag W, Baum C, Stocking C. Will E, et al. Nucleic Acids Res. 2002 Jun 15;30(12):e59. doi: 10.1093/nar/gnf059. Nucleic Acids Res. 2002. PMID: 12060697 Free PMC article.
Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation.
Ennifar E, Meyer JE, Buchholz F, Stewart AF, Suck D. Ennifar E, et al. Nucleic Acids Res. 2003 Sep 15;31(18):5449-60. doi: 10.1093/nar/gkg732. Nucleic Acids Res. 2003. PMID: 12954782 Free PMC article.

References

1. Buchholz F., Refaeli, Y., Trumpp, A. and Bishop, J.M. (2000) Inducible chromosomal translocation of AML and ETO genes through Cre-loxP-mediated recombination in the mouse. EMBO Rep., 1, 133–139. - PMC - PubMed
1. Collins E.C., Pannell, R., Simpson, E.M., Forster, A. and Rabbitts, T.H. (2000) Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep., 1, 127–132. - PMC - PubMed
1. Corral J. et al. (1996) An Mll–AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell, 85, 853–861. - PubMed
1. Dobson C.L., Warren, A.J., Pannell, R., Forster, A., Lavenir, I., Corral, J., Smith, A.J. and Rabbitts, T.H. (1999) The mll–AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J., 18, 3564–3574. - PMC - PubMed
1. Golic K.G. (1991) Site-specific recombination between homologous chromosomes in Drosophila. Science, 252, 958–961. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources