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. 2001 Mar 12;11(5):641-5.
doi: 10.1016/s0960-894x(01)00029-4.

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

J M Fevig  1 , D J Pinto, Q Han, M L Quan, J R Pruitt, I C Jacobson, R A Galemmo Jr, S Wang, M J Orwat, L L Bostrom, R M Knabb, P C Wong, Lam PYS, R R Wexler
Affiliations

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

J M Fevig et al. Bioorg Med Chem Lett. .

Abstract

The selective inhibition of coagulation factor Xa has emerged as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe highly potent benzamidine factor Xa inhibitors based on a vicinally-substituted heterocyclic core.

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