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. 2001 Jan;54(1):56-65.
doi: 10.7164/antibiotics.54.56.

Extremophilic orgainisms as and unexplored source fo antifungal compounds

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Free article

Extremophilic orgainisms as and unexplored source fo antifungal compounds

C H Phoebe Jr et al. J Antibiot (Tokyo). 2001 Jan.
Free article

Abstract

Extracts of the biomasses and fermentation broths of 217 extremophilic microorganisms isolated from a number of locales were screened for antifungal activity using whole-cell and mechanism-based in vitro assays. Importantly, eleven broth extracts had activity against several Candida species and Aspergillus fumigatus in whole-cell in vitro assays. One broth specifically inhibited (1,3)beta-glucan synthase activity and four specifically inhibited ketol-isomerase activity, suggesting a mode of action of the antifungal compound(s) present in these extracts. The extract from one thermophile, a novel species of Pseudomonas, was fractionated, an active compound purified and its structure determined. The compound was identified as pyochelin, a previously identified iron-binding compound with heretofore undescribed antifungal activity. To our knowledge, this is the first report demonstrating that extremophiles synthesize compounds that have antifungal activity.

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