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. 2000;46(5):14-8.

[Role of estrogens in the regulation of puberty in female rats]

[Article in Ukrainian]
L B Litvinova  1
Affiliations
  • PMID: 11269846

[Role of estrogens in the regulation of puberty in female rats]

[Article in Ukrainian]
L B Litvinova. Fiziol Zh (1994). 2000.

Abstract

Various correlations of testosterone metabolites during puberty were modulated in female rats. It has been fixed that estrogenes stimulate female pubescence only under conditions of non-aromatized androgenes availability in organism. Role of estrogenes in first-stage puberty (vagina opening) consists in activation of fermentative (5a-reductive) system which realises testosterone biotransformation into 5 alpha-reduced androgenes. Being dependent on the dose estrogenes shorten the period between initial and final (establishing positive feed-back way in ovaries-hypophysis system) puberty stages, hasten the first ovulation.

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