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. 2001 Mar 27;56(6):784-5.
doi: 10.1212/wnl.56.6.784.

Recurrence risks to sibs of MS index cases: impact of consanguineous matings

A Dessa Sadovnick  1 , I M Yee, G C Ebers; Canadian Collaborative Study Group
Affiliations

Recurrence risks to sibs of MS index cases: impact of consanguineous matings

A Dessa Sadovnick et al. Neurology. .

Abstract

Using population-based data, the authors identified 24 MS index cases whose parents were related. Twenty-two had 67 sibs of whom 6 also had MS, yielding a recurrence risk of approximately 9%, significantly higher than for sibs of MS index cases from nonconsanguineous parents. These findings support the concept that multiple interacting genes increase the risk of MS.

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