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Review
. 2001 Apr;22(4):205-11.
doi: 10.1016/s1471-4906(01)01873-7.

IgA and the IgA Fc receptor

M van Egmond  1 , C A Damen, A B van Spriel, G Vidarsson, E van Garderen, J G van de Winkel
Affiliations
Review

IgA and the IgA Fc receptor

M van Egmond et al. Trends Immunol. 2001 Apr.

Abstract

IgA has traditionally been regarded a non-inflammatory antibody. This might indeed be true for secretory IgA (SIgA), which exerts its function at mucosal surfaces where commensal microorganisms and dietary antigens prevail. Serum IgA, however, potently triggers (pro)-inflammatory activity upon binding to the myeloid IgA receptor, FcalphaRI. Here, new insights in the roles of IgA and FcalphaRI are addressed and a model integrating the various functions of IgA in immunity is discussed.

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Comment in

  • Confusion about the polymeric Ig receptor.
    Brandtzaeg P, Johansen FE. Brandtzaeg P, et al. Trends Immunol. 2001 Oct;22(10):545-6. doi: 10.1016/s1471-4906(01)02032-4. Trends Immunol. 2001. PMID: 11702721 Review. No abstract available.

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