Review
doi: 10.2174/0929867003373319.
Sequence recognition of DNA by lexitropsins
Affiliations
- PMID: 11281838
- DOI: 10.2174/0929867003373319
Item in Clipboard
Review
Sequence recognition of DNA by lexitropsins
Curr Med Chem.
2001 Apr.
Abstract
Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits--pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.
Similar articles
-
Recent developments in sequence selective minor groove DNA effectors.Curr Med Chem. 2001 Apr;8(5):475-508. doi: 10.2174/0929867003373292. Curr Med Chem. 2001. PMID: 11281837 Review.
-
Ligands recognizing the minor groove of DNA: development and applications.Biopolymers. 1999-2000;52(4):197-211. doi: 10.1002/1097-0282(1999)52:4<197::AID-BIP1004>3.0.CO;2-U. Biopolymers. 1999. PMID: 11295751
-
Carbocyclic analogues of lexitropsin--DNA affinity and endonuclease inhibition.Acta Pol Pharm. 2007 Mar-Apr;64(2):115-9. Acta Pol Pharm. 2007. PMID: 17665860
-
DNA recognition by lexitropsins, minor groove binding agents.J Mol Recognit. 1994 Jun;7(2):79-88. doi: 10.1002/jmr.300070205. J Mol Recognit. 1994. PMID: 7826677 Review.
-
Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin--new carriers of alkylating elements.Acta Biochim Pol. 2000;47(1):23-35. Acta Biochim Pol. 2000. PMID: 10961675
Cited by
-
Role of stacking interactions in the binding sequence preferences of DNA bis-intercalators: insight from thermodynamic integration free energy simulations.Nucleic Acids Res. 2005 Nov 10;33(19):6214-24. doi: 10.1093/nar/gki916. Print 2005. Nucleic Acids Res. 2005. PMID: 16282585 Free PMC article.
-
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.Nucleic Acids Res. 2003 Nov 1;31(21):6064-78. doi: 10.1093/nar/gkg815. Nucleic Acids Res. 2003. PMID: 14576293 Free PMC article. Review.
-
Knowledge-based elastic potentials for docking drugs or proteins with nucleic acids.Biophys J. 2005 Feb;88(2):1166-90. doi: 10.1529/biophysj.104.043612. Epub 2004 Oct 22. Biophys J. 2005. PMID: 15501936 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
