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. 2001 Apr;75(1):33-6.
doi: 10.1016/s0378-8741(00)00391-3.

Antihypertensive and vasorelaxant effects of aqueous extract from Croton schiedeanus Schlecht in rats

M F Guerrero  1 , R Carrón, M L Martín, L San Román, M T Reguero
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Antihypertensive and vasorelaxant effects of aqueous extract from Croton schiedeanus Schlecht in rats

M F Guerrero et al. J Ethnopharmacol. 2001 Apr.

Abstract

Antihypertensive and vasorelaxant effects of treatment with the aqueous extract of Croton schiedeanus Schlecht (AECS) were investigated in anaesthetized spontaneously hypertensive rats (SHR). Intravenous bolus injections of AECS (5-100 mg/kg) elicited dose-dependent decreases in mean arterial pressure (MAP) and heart rate (HR). Additionally, AECS (10(-6)-3x10(-3)g/ml) completely relaxed the contractions induced by high K(+) concentrations in intact rat aortic rings in a concentration-dependent manner.

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