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Clinical Trial
. 2001 Apr;158(4):635-7.
doi: 10.1176/appi.ajp.158.4.635.

Effects of sustained-release bupropion and supportive group therapy on cigarette consumption in patients with schizophrenia

E Weiner  1 , M P Ball, A Summerfelt, J Gold, R W Buchanan
Affiliations
Clinical Trial

Effects of sustained-release bupropion and supportive group therapy on cigarette consumption in patients with schizophrenia

E Weiner et al. Am J Psychiatry. 2001 Apr.

Abstract

Objective: The study examined the efficacy, tolerability, and safety of supportive group psychotherapy and adjunctive sustained-release bupropion for nicotine addiction in patients with schizophrenia.

Method: Eight patients participated in a 14-week open-label trial. End expired breath carbon monoxide level, symptom levels, neuropsychological performance, and suppression of the P50 event-related potential were measured before and after the 14-week trial.

Results: Patients showed a decrease in carbon monoxide levels that was not associated with any worsening in symptom, neuropsychological, or P50 suppression measures.

Conclusions: Use of sustained-release bupropion in combination with supportive group therapy may help patients with schizophrenia decrease their cigarette consumption.

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