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Case Reports
. 2001 Apr;39(4):1580-5.
doi: 10.1128/JCM.39.4.1580-1585.2001.

Isolation of Helicobacter cinaedi from the colon, liver, and mesenteric lymph node of a rhesus monkey with chronic colitis and hepatitis

J G Fox  1 , L Handt, B J Sheppard, S Xu, F E Dewhirst, S Motzel, H Klein
Affiliations
Case Reports

Isolation of Helicobacter cinaedi from the colon, liver, and mesenteric lymph node of a rhesus monkey with chronic colitis and hepatitis

J G Fox et al. J Clin Microbiol. 2001 Apr.

Abstract

On the basis of biochemical, phenotypic, and 16S rRNA analyses, Helicobacter cinaedi was isolated from the colon, liver, and mesenteric lymph nodes of a 2-year-old rhesus monkey with chronic diarrhea. Histologically, the liver had mild to moderate biliary hyperplasia and hypertrophy with periportal inflammation and fibrosis. Colonic and cecal lesions consisted of diffuse chronic inflammation and glandular hyperplasia extending the length of the crypts. This is the first observation of H. cinaedi associated with active hepatitis and colitis in a nonhuman primate.

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Figures

FIG. 1
FIG. 1
Liver. (a) Portal inflammation with mild peribiliary collagen deposition. (b) Elongated bile duct profiles. (c) Hematoxylin and eosin stain showing centrolobular inflammation. Magnification, ×156 for all panels.
FIG. 1
FIG. 1
Liver. (a) Portal inflammation with mild peribiliary collagen deposition. (b) Elongated bile duct profiles. (c) Hematoxylin and eosin stain showing centrolobular inflammation. Magnification, ×156 for all panels.
FIG. 1
FIG. 1
Liver. (a) Portal inflammation with mild peribiliary collagen deposition. (b) Elongated bile duct profiles. (c) Hematoxylin and eosin stain showing centrolobular inflammation. Magnification, ×156 for all panels.
FIG. 2
FIG. 2
(a and b) Cecal inflammation. Magnifications, ×162 and ×324, respectively. (c and d) Hematoxylin and eosin stain showing colonic inflammation. Magnifications, ×81 and ×324, respectively.
FIG. 3
FIG. 3
Mesenteric lymph node. (a) Marked hypercellularity of cortex and medulla. Magnification, ×80. (b) Medullary histiocytic infiltrate. Magnification, ×160. (c) Hematoxylin and eosin stain showing inflamed cecal mesentery. Magnification, ×320.
See this image and copyright information in PMC

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