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Review
. 2001 Apr;2(4):294-307.
doi: 10.1038/35067100.

Cbl: many adaptations to regulate protein tyrosine kinases

C B Thien  1 , W Y Langdon
Affiliations
Review

Cbl: many adaptations to regulate protein tyrosine kinases

C B Thien et al. Nat Rev Mol Cell Biol. 2001 Apr.

Abstract

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

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