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Review
. 2001 Jan;22(1):17-20.
doi: 10.1016/s1471-4906(00)01795-6.

Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization

C D Tsoukas  1 , J A Grasis, K A Ching, Y Kawakami, T Kawakami
Affiliations
Review

Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization

C D Tsoukas et al. Trends Immunol. 2001 Jan.

Abstract

Itk/Emt, a tec family tyrosine kinase, is important for T-cell development and activation through the antigen receptor. Here, we review data suggesting that Itk/Emt is involved in the generation of critical second messengers (Ca(2+), PKC) whose duration it modulates by regulation of cytoskeletal reorganization. We propose that Itk/Emt constitutes an important link between these critical signaling events.

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