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Review
. 2001 Jan;22(1):21-6.
doi: 10.1016/s1471-4906(00)01798-1.

Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question

M F Neurath  1 , S Finotto, I Fuss, M Boirivant, P R Galle, W Strober
Affiliations
Review

Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question

M F Neurath et al. Trends Immunol. 2001 Jan.

Erratum in

  • Trends Immunol 2001 Apr;22(4):225

Abstract

T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.

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