Review
doi: 10.1016/s1471-4906(00)01812-3.
RANTES: a versatile and controversial chemokine
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- PMID: 11286708
- DOI: 10.1016/s1471-4906(00)01812-3
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Review
RANTES: a versatile and controversial chemokine
Trends Immunol.
2001 Feb.
Abstract
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.
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