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Review
. 2001 Mar;22(3):130-6.
doi: 10.1016/s1471-4906(00)01844-5.

A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo

P K Das  1 , R M van den Wijngaard, A Wankowicz-Kalinska, I C Le Poole
Affiliations
Review

A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo

P K Das et al. Trends Immunol. 2001 Mar.

Abstract

Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.

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