Synthesis of high affinity antibodies in irradiated rabbits grafted with allogeneic cells from hyperimmune donors
- PMID: 112911
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Synthesis of high affinity antibodies in irradiated rabbits grafted with allogeneic cells from hyperimmune donors
Ann Immunol (Paris).
1979 May-Jun.
Abstract
Irradiated rabbits grafted with allogeneic lymph node, spleen and bone marrow cells from a donor rabbit hyperimmunized against TMV synthesize high affinity antibodies, displaying mainly recipient allotypic specificities, after antigen boosting. By contrast, recipient rabbits from non-immune donors synthesize antibodies of lower affinity. It is suggested that the differentiation of new emerging host B cells is specifically influenced by the presence of donor-memory cells.
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