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. 1979 May-Jun;130C(3):385-96.

Synthesis of high affinity antibodies in irradiated rabbits grafted with allogeneic cells from hyperimmune donors

A Van Acker, G Urbain-Vansanten, C De Vos-Cloetens, N Tasiaux, J Urbain
  • PMID: 112911

Synthesis of high affinity antibodies in irradiated rabbits grafted with allogeneic cells from hyperimmune donors

A Van Acker et al. Ann Immunol (Paris). 1979 May-Jun.

Abstract

Irradiated rabbits grafted with allogeneic lymph node, spleen and bone marrow cells from a donor rabbit hyperimmunized against TMV synthesize high affinity antibodies, displaying mainly recipient allotypic specificities, after antigen boosting. By contrast, recipient rabbits from non-immune donors synthesize antibodies of lower affinity. It is suggested that the differentiation of new emerging host B cells is specifically influenced by the presence of donor-memory cells.

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