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Comment
. 2001 Apr 20;292(5516):449-51.
doi: 10.1126/science.1060849. Epub 2001 Apr 5.

Signal transduction. How do cells sense oxygen?

H Zhu  1 , H F Bunn
Affiliations
Comment

Signal transduction. How do cells sense oxygen?

H Zhu et al. Science. .

Abstract

How do organisms sense the amount of oxygen in the environment and respond appropriately when the amount of oxygen decreases (a condition called hypoxia)? In their Perspective, Zhu and Bunn discuss new findings (Ivan et al., Jaakkola et al.) that reveal how the HIF transcription factor, which switches on a group of hypoxia-response proteins, is itself regulated by changes in oxygen tension. The authors are in the Hematology Division of the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. E-mail: zhu@calvin.bwh.harvard.edu, bunn@calvin.bwh.harvard.edu

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References

    1. Ivan M, et al. Science. 2001 April 5; (10.1126/science.1059817). Include this information when citing this paper.
    1. Jaakkola P, et al. Science. 2001 April 5; (10.1126/science.1059796). Include this information when citing this paper.
    1. Semenza GL. Annu. Rev. Cell Dev. Biol. 1999;15:551. - PubMed
    1. Gilles-Gonzalez MA, Ditta GS, Helinski DR. Nature. 1991;350:170. - PubMed

    1. Mammalian HIFα includes HIF-1α and its homolog HIF-2α (EPAS1), which has a more limited range of tissue expression. Other HIFα homologs have been reported but are not known to be regulated by oxygen-dependent degradation.

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