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. 2001 Apr 6;292(5514):104-6.
doi: 10.1126/science.1057991.

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

D J Clancy  1 , D Gems, L G Harshman, S Oldham, H Stocker, E Hafen, S J Leevers, L Partridge
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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

D J Clancy et al. Science. .

Abstract

The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

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Comment in

  • Longevity. Growing old together.
    Strauss E. Strauss E. Science. 2001 Apr 6;292(5514):41-3. doi: 10.1126/science.292.5514.41. Science. 2001. PMID: 11294208 No abstract available.

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