Aortic histomine syntesis in experimental neurogenic hypertension

Abstract

Aortic histamine synthesis of normotensive rats has been compared to that of rats rendered hypertensive via production carotid sinus ischemia and to animals additionally subjected to bilateral adrenalectomy. Results indicate that the aortic histamine-forming capacities (HFC's) of rats sacrificed 24 hr after surgical treatment were elevated 83% and 103% for hypertensive rats and those additionally subjected to adrenalectomy, respectively. At an 8-day postoperative interval, the respective aortic HFC's were elevated over control by 33% and 45%, although at this time interval animals were not considered hypertensive. This study thus offers suggestive evidence that hypertension causes increased vascular permeability by increasing the histamine-forming capacity of the vessel wall.