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Clinical Trial
. 2001 Jan-Feb;56(11):827-9.
doi: 10.1007/s002280000253.

In vivo measurement of [11C]verapamil kinetics in human tissues

N H Hendrikse  1 , E G de Vries, E J Franssen, W Vaalburg, W T van der Graaf
Affiliations
Clinical Trial

In vivo measurement of [11C]verapamil kinetics in human tissues

N H Hendrikse et al. Eur J Clin Pharmacol. 2001 Jan-Feb.

Abstract

Objective: To evaluate [11C]verapamil kinetics in humans.

Methods: After intravenous injection of [11C]verapamil (370 MBq, specific activity >1,600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET).

Results: One hour after injection, accumulation of [11C] in lungs, heart and tumour was 43.0%, 1.3% and 0.9% of the injected verapamil dose, respectively. Half-lives of [11C]verapamil in these tissues were 46.2 min, 73.8 min and 23.7 min, respectively.

Conclusions: Intravenously administered [11C] was mainly extracted by the lungs. Transport of a [11C]verapamil bolus out of solid tumour tissue is relatively fast.

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