Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Mar;28(3):533-8.

Quantitative analyses of messenger RNA of human endogenous retrovirus in patients with systemic lupus erythematosus

H Ogasawara  1 , T Naito, H Kaneko, T Hishikawa, I Sekigawa, H Hashimoto, Y Kaneko, N Yamamoto, N Maruyama, N Yamamoto
Affiliations
  • PMID: 11296954

Quantitative analyses of messenger RNA of human endogenous retrovirus in patients with systemic lupus erythematosus

H Ogasawara et al. J Rheumatol. 2001 Mar.

Abstract

Objective: Human endogenous retrovirus (HERV) has emerged as a possible causative agent of systemic lupus erythematosus (SLE). To investigate the role of HERV in the etiology of SLE, we performed quantitative analyses of messenger RNA (mRNA) of the HERV clone 4-1 in patients with SLE.

Methods: Reverse transcriptase (RT)-polymerase chain reaction (PCR) and real-time quantitative PCR (RQ-PCR; TaqMan methodology) were used in this experiment.

Results: The quantities of mRNA of the HERV clone 4-1 gag region in patients with SLE were significantly higher than in healthy controls, and the amounts of such mRNA in the patients were decreased by steroid treatment.

Conclusion: These phenomena may be related to the production of viral components derived from HERV clone 4-1 and contribute to the pathogenesis of SLE; studies using a larger number of patients are required to confirm these points.

PubMed Disclaimer

Comment in

Publication types

LinkOut - more resources