The joint toxic action of perchloroethylene with benzene or toluene in rats

Abstract

The joint toxic action of mixtures of perchloroethylene with benzene or toluene was tested at five dose levels for each of six binary combinations with 20 rats per dose. LD50 data with 95% fiducial limits are reported for each mixture and tests for additive joint toxicity were made. The results indicate that the mixtures of perchloroethylene and benzene gave values for the LD50 which were slightly less than additive while perchloroethylene and toluene mixtures had LD50 values which could not be predicted by an additive model.