Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2001;3(3):178-82.
doi: 10.1186/ar295. Epub 2001 Feb 19.

Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

A Scheja  1 , A Akesson, P Geborek, M Wildt, C B Wollheim, F A Wollheim, U M Vischer
Affiliations
Comparative Study

Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

A Scheja et al. Arthritis Res. 2001.

Abstract

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

PubMed Disclaimer

Figures

Supplementary Figure 1
Supplementary Figure 1
Plasma levels of vWf and its propeptide in 44 patients with SSc, grouped according to the degree of skin involvement. Medians are marked with horizontal bars.
See this image and copyright information in PMC

References

    1. Kahaleh MB, Osborn I, LeRoy EC. Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud's phenomenon. Ann Int Med. 1981;94:482–484. - PubMed
    1. Ohdama S, Takano S, Miyake S, Kubota T, Sato K, Aoki N. Plasma thrombomodulin as a marker of vascular injuries in collagen vascular diseases. Am J Clin Pathol. 1994;101:109–113. - PubMed
    1. Kahaleh MB. Endothelin, an endothelial-dependent vasoconstrictor in scleroderma: enhanced production and profibrotic action. Arthritis Rheum. 1991;34:978–983. - PubMed
    1. Pedrinelli R, Giampietro O, Carmassi F, Melillo E, Dell'Omo G, Catapano G, Matteucci E, Talarico L, Morale M, De Negri F, et al. Microalbuminuria and endothelial dysfunction in essential hypertension. Lancet. 1994;344:14–18. - PubMed
    1. Jensen T, Bjerre-Knudsen J, Feldt-Rasmussen B, Deckert T. Features of endothelial dysfunction in early diabetic nephropathy. Lancet. 1989;i:461–463. - PubMed

Publication types