[Carcinogenic activity of a 4,4-diaminobiphenyl ester]

Abstract

4,4'-diaminodiphenyl ether (dadpe) was injected subcutaneously (once a week) or given per orally (1-5 times a week) in rats in a dose of 25 mg/per rat and in mice of line CC57W in a dose of 5 mg/per mouse. Administration of the substance produced in mice and rats under study renal lesions of the nephrosis type with a nephritic component. In later stages of the experiment some rats showed adenomatous regeneration and formation of renal cysts, in one rat hypernephroid cancer of the kidney was observed. Tumors of different localizations were found in 44% of rats (in 7 of 16 animals), and in 57% of mice (in 8 of 14 animals) in experiments with peroral administration of the substance; in 18% of rats (in 7 of 39 animals) and in 33% of mice (in 3 of 9 animals) in experiments with subcutaneous injection of the substance. The results of the experiments have evidenced an insignificant blastomogenic action of 4,4'-diaminodiphenyl ether.