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. 2001 Feb;54(2):157-65.
doi: 10.7164/antibiotics.54.157.

Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain

N Morisaki  1 , Y Hashimoto, K Furihata, K Yazawa, M Tamura, Y Mikami
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Free article

Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain

N Morisaki et al. J Antibiot (Tokyo). 2001 Feb.
Free article

Abstract

Studies on the susceptibility of pathogenic Nocardia to macrolide antibiotics, chalcomycin and tylosin, showed that most of the Nocardia species examined were highly resistant to both antibiotics, although N. nova was moderately susceptible. N. asteroides IFM 0339 converted these macrolides into inactive metabolites by glycosylation at 2'-OH or glycosylation and reduction of the 20-formyl group. The structures of the metabolites were determined from NMR and MS data to be 2'-[O-(beta-D-glucopyranosyl)]chalcomycin (2), 2'-[O-(beta-D-glucopyranosyl)]tylosin (5) and 20-dihydro-2'-[O-(beta-D-glucopyranosyl)]tylosin (4).

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