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Review
. 2001 Apr;24(4):277-80.
doi: 10.1002/clc.4960240404.

Lessons learned from statin trials

Affiliations
Review

Lessons learned from statin trials

J Auer et al. Clin Cardiol. 2001 Apr.

Abstract

This article aims to review lessons learned about lipid lowering and statins in the past decade and to consider what developments the future may hold. Results from a series of landmark clinical trials confirm that statins significantly reduce cardiovascular morbidity and mortality in patients with and without previous coronary artery disease. The potential of this drug class has yet to be fully explored. Studies currently under way will answer many of the outstanding questions.

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    1. Alberts AW, Chen J, Kuron G, Hunt V, Huff J, Hoffman C, Rothrock J, Lopez M, Joshua H, Harris E, Patchett A, Monaghan R, Currie S, Stapley E, Albers‐Schonberg G, Hensens O, Hirshfield J, Hoogsteen K, Liesch J, Springer J, Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl‐coenzyme A reductase and a cholesterol‐lowering agent. Proc Natl Acad Sci USA 1980; 77 (7): 3957–3961 - PMC - PubMed
    1. Slater EE, MacDonald JS: Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs 1988; 36 (suppl 3): 72–82 - PubMed
    1. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 1995; 333: 1301–1307 - PubMed
    1. Downs JR, Clearfield M, Weis S, Whitney E, Shapiro DR, Beere PA, Langendorfer A, Stein EA, Kruyer W, Gotto AM Jr: Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS. Airforce/Texas Coronary Atherosclerosis Prevention Study. J Am Med Assoc 1998; 279: 1615–1622 - PubMed
    1. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383–1389 - PubMed

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