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Comparative Study
. 2001 Apr 17;12(5):935-8.
doi: 10.1097/00001756-200104170-00014.

Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy

T Arai  1 , K Ikeda, H Akiyama, K Tsuchiya, S Yagishita, J Takamatsu
Affiliations
Comparative Study

Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy

T Arai et al. Neuroreport. .

Abstract

Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) are sporadic neurodegenerative diseases with intracytoplasmic aggregates of the microtubule-associated protein, tau, in neurons and glial cells. Immunoblot analysis of detergent-insoluble brain extracts of patients with CBD and PSP shows distinctive patterns of tau fragments. These results suggest differing intracellular processing of aggregated tau in these two diseases despite an identical composition of tau isoforms. Such biochemical differences may be related to the neuropathological features of these diseases.

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