Biodegradable polylactate as a steroid-releasing polymer: intrauterine administration of d-norgestrel

Abstract

Polylactate film containing 30 per cent or 4.5 mg. of d-norgestrel was fixed around a plain T-IUD and the device was inserted into the uterine cavity. Norgestrel was gradually released into the systemic circulation, blood levels being highest during menstruation. Plasma estradiol and progesterone determinations revealed that cyclic ovarian function was maintained during the intrauterine administration of norgestrel; however, marked local effects on the endometrium resulted. The amount of menstrual bleeding was reduced.

PIP: Biodegradable polylactate as a steroid-releasing polymer for the intrauterine administration of d-norgestrel was investigated. Polylactate film containing 30% or 4.5 mg of d-norgestrel was fixed around a plain T-intrauterine device and inserted into the uterine cavity of 5 healthy women, aged 25-33 years. Norgestrel was gradually released into the systemic circulation and the blood levels were highest during menstruation. Plasma estradiol and progesterone determination revealed that cyclic ovarian function was maintained during the administration of norgestrel. Cyclic endometrial changes were markedly reduced, and menstrual bleeding decreased. The women ovulated during the treatment cycle. Normal sexual activities were carried on and no pregnancy occurred.