Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001;2(4):REVIEWS0003.
doi: 10.1186/gb-2001-2-4-reviews0003. Epub 2001 Apr 5.

A tale of histone modifications

P A Grant  1
Affiliations
Review

A tale of histone modifications

P A Grant. Genome Biol. 2001.

Abstract

The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications and the enzymatic machines that generate them.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A model for the generation of transcriptionally active and inactive chromatin domains by post-translational histone modification. (a) Histone acetyltransferases (HATs) generate patterns of acetylation (Ac) recognized by other transcriptional regulators, such as the bromodomain-containing (Bromo) factors TAFII250, PCAF and GCN5, leading to chromatin 'opening' and gene activation. (b) Conversely, the conserved histone methyltransferase (HMT) SUV39H1 methylates (Me) histone H3, which is then bound by the heterochromatin-associated chromodomain (Chromo) protein HP1/Swi6, establishing a silent chromatin domain.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Luger K, Mader AW, Richmond R, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 ? resolution. Nature. 1997;389:251–260. - PubMed
    1. Wu J, Grunstein M. 25 years after the nucleosome model: chromatin modifications. Trends Biochem Sci. 2000;25:619–623. - PubMed
    1. Allfrey VG, Faulkner R, Mirsky AE. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc Natl Acad Sci USA. 1964;51:786–794. - PMC - PubMed
    1. Grant PA, Berger SL. Histone acetyltransferase complexes. Semin Cell Dev Biol. 1999;10:169–177. - PubMed
    1. Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem. 2001;70:81–120. - PubMed

Publication types

LinkOut - more resources