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. 2001 Apr;107(8):935-41.
doi: 10.1172/JCI12802.

Syndecans: transmembrane modulators of adhesion and matrix assembly

A Woods  1
Affiliations

Syndecans: transmembrane modulators of adhesion and matrix assembly

A Woods. J Clin Invest. 2001 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Schematic diagram of the known interactions of syndecan core proteins. The GAG chains on the ectodomain are indicated by white lines, and the cytoplasmic domain is divided into the C1, V, and C2 regions. Molecules known to interact with different sites within the core protein are indicated. CBD, cell binding domain; TM, transmembrane domain.
Figure 2
Figure 2
Focal adhesions and stress fiber formation. (a) Syndecan-4 is diffusely distributed in the membrane, as is the phospholipid PIP2 (yellow). PKCα (red ovals) is cytosolic under these conditions. (b) Following interaction with ligand (blue), syndecan-4 becomes clustered into forming focal adhesions. This clustering is stabilized by PIP2 and allows binding and superactivation of PKCα, leading to the phosphorylation of focal adhesion proteins. The actin microfilament system is condensed at focal adhesions, inducing the formation of stress fibers. Shed forms of syndecan-4 may interfere with the cell’s ability to reorganize its cytoskeleton in response to adhesive interactions. The function of syndecan-4, either in its membrane-bound form or in solution, is analogous to that of a number of matricellular proteins described elsewhere in this Perspective series.
See this image and copyright information in PMC

References

    1. Rapraeger AC. Syndecan-regulated receptor signaling. J Cell Biol. 2000;149:995–997. - PMC - PubMed
    1. Bernfield M, et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem. 1999;68:729–778. - PubMed
    1. Couchman, J.R., Chen, L., and Woods, A. 2001. Syndecans and cell adhesion. Int. Rev. Cytol. In press. - PubMed
    1. Woods A, Couchman JR. Integrin modulation by lateral association. J Biol Chem. 2000;275:24233–24236. - PubMed
    1. Tumova S, Woods A, Couchman JR. Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions. Int J Biochem Cell Biol. 2000;32:269–288. - PubMed

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