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. 2001 Mar 17;30(10):511-4.

[Cyclooxygenases]

[Article in French]
P Eschwège  1 , V de Ledinghen, T Camilli, S Kulkarni, G Dalbagni, S Droupy, A Jardin, G Benoît, B B Weksler
Affiliations
  • PMID: 11307497

[Cyclooxygenases]

[Article in French]
P Eschwège et al. Presse Med. .

Abstract

TWO ISOFORMS: There are two isoforms of cyclooxygenase (COX) with similar structure and metabolic activity. COX-1 is a constitutional enzyme. COX-2 is an inductible form. CYCLOOXYGENASE-1: COX-1 is present in most tissues, particularly in the kidney, the digestive tract mucosa, platelets, brain, liver and spleen. CYCLOOXYGENASE-2: COX-2 expression can be induced by an inflammatory process. Implicated in the development of certain cancers, COX-2 is expressed in numerous tumor cell lines and in most epithelial carcinomas. COX-2 favors tumor invasion and inhibits apoptosis. When it is absent, tumor growth is slower or stopped.

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