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Editorial
. 2001 Mar;123(3):347-9.
doi: 10.1046/j.1365-2249.2001.01470.x.

NF-kappa B may determine whether epithelial cell--microbial interactions in the intestine are hostile or friendly

Y R Mahida, S Johal
Editorial

NF-kappa B may determine whether epithelial cell--microbial interactions in the intestine are hostile or friendly

Y R Mahida et al. Clin Exp Immunol. 2001 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1
A model of NF‐κB activation in intestinal epithelial cells. Pathogenic bacteria and pro‐inflammatory cytokines induce phosphorylation of IκB via the IκB kinase complex. Ubiquitin polypeptides are attached to phosphorylated IκB with its subsequent degradation by the 26S proteasome complex. The active NFκB dimer then migrates to the nucleus and binds to its sequence recognition motif on the promoter region of IL‐8 gene, leading to transcription and translation of the chemokine. Non‐pathogenic bacteria can inhibit IκB degradation by abrogating the polyubiquitination step, and thereby inhibit expression of IL‐8 because NF‐κB is retained in the cytoplasm.
See this image and copyright information in PMC

Comment on

References

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