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Review
. 2001 Mar;6(2):95-103.
doi: 10.1023/a:1011401825680.

The role of interleukin-6 in the failing heart

K C Wollert  1 , H Drexler
Affiliations
Review

The role of interleukin-6 in the failing heart

K C Wollert et al. Heart Fail Rev. 2001 Mar.

Abstract

Clinical studies have shown that circulating levels of interleukin (IL)-6 and other IL-6 related cytokines are increased in patients with congestive heart failure (CHF). Plasma IL-6 concentrations are related to decreasing functional status of the patient and provide important prognostic information. Experimental studies have produced compelling evidence that IL-6 and IL-6 related cytokines play a pivotal role in the regulation of cardiac myocyte hypertrophy and apoptosis. This review summarizes clinical and experimental data from this rapidly evolving field, which, taken together, strongly suggest that IL-6 and IL-6 related cytokines are intricately involved in the pathophysiology of the failing heart.

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References

    1. J Am Coll Cardiol. 1999 Dec;34(7):2061-7 - PubMed
    1. Circulation. 1998 Jul 28;98(4):346-52 - PubMed
    1. J Am Coll Cardiol. 1996 Apr;27(5):1201-6 - PubMed
    1. Blood. 1993 Aug 15;82(4):1120-6 - PubMed
    1. J Exp Med. 1996 Apr 1;183(4):1399-406 - PubMed

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