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Case Reports
. 2000 Dec;52(12):521-6.

[Endometrial adenocarcinoma appearing during tamoxifen therapy. Report of a clinical case]

[Article in Italian]
M V Menada  1 , A Corticelli, A Giannesi, L Nicoletti, M Podesta, R Rissone, E Fulcheri
Affiliations
  • PMID: 11310150
Case Reports

[Endometrial adenocarcinoma appearing during tamoxifen therapy. Report of a clinical case]

[Article in Italian]
M V Menada et al. Minerva Ginecol. 2000 Dec.

Abstract

Tamoxifen is a non-steroid estrogenic antagonist, used in post-surgical therapy of breast cancer. It interferes with endocrinous promotion of breast cancer. Tamoxifen could determine endometrial, even carcinomatous, alterations. The case of a postmenopausal patient surgically treated for breast cancer and successively treated with tamoxifen (20 mg/die), is reported. She underwent ultrasonographic and hysterosonographic endometrial evaluation and finally a hysterectomy with bilateral annessiectomy. This case seems to confirm tamoxifen possible carcinogenical effects on the endometrium.

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