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. 2001 May 1;355(Pt 3):765-70.
doi: 10.1042/bj3550765.

Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' disease

M Wainszelbaum  1 , E Isola, S Wilkowsky, J J Cannata, J Florin-Christensen, M Florin-Christensen
Affiliations

Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' disease

M Wainszelbaum et al. Biochem J. .

Abstract

We found that, as in African trypanosomes, endogenous phospholipase A(1) (Plase A(1)) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A(1) was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A(1) emerges as a target to block pathogenesis in trypanosomal infections.

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