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Review
. 2001 Apr 21;322(7292):989-91.
doi: 10.1136/bmj.322.7292.989.

Interpreting the results of secondary end points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic?

Affiliations
Review

Interpreting the results of secondary end points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic?

N Freemantle. BMJ. .
No abstract available

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References

    1. Packer M, O'Connor CM, Ghali JK, Pressler ML, Carson PE, Belkin RN, et al. Effect of amlodipine on morbidity and mortality in severe chronic heart failure. N Engl J Med. 1996;335:1107–1114. - PubMed
    1. Department of Health and Human Services. Food and Drug Administration. International conference on harmonisation; guidance on statistical principles for clinical trials. Federal Register. 1998;63:49583–49598. . (Docket no 97D-0174.) - PubMed
    1. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology. 1990;1:43–46. - PubMed
    1. Perneger TV. What's wrong with Bonferroni adjustments? BMJ. 1998;316:1236–1238. - PMC - PubMed
    1. Fisher LD. Carvedilol and the Food and Drug Administration (FDA) approval process: the FDA paradigm and reflections on hypothesis testing. Control Clin Trials. 1999;20:16–39. - PubMed

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