Bioactive constituents from gum guggul (Commiphora wightii)
- PMID: 11314959
- DOI: 10.1016/s0031-9422(00)00485-4
Bioactive constituents from gum guggul (Commiphora wightii)
Abstract
Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.
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