Comment on

• Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I.

  Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, Bikle DD. Kostenuik PJ, et al. J Bone Miner Res. 1999 Jan;14(1):21-31. doi: 10.1359/jbmr.1999.14.1.21. J Bone Miner Res. 1999. PMID: 9893062
• Clinical vignette. Vitamin K plus vitamin D treatment of bone problems in a child with skeletal unloading.

  Sugiyama T, Tanaka H, Kawai S. Sugiyama T, et al. J Bone Miner Res. 1999 Aug;14(8):1466-7. doi: 10.1359/jbmr.1999.14.8.1466. J Bone Miner Res. 1999. PMID: 10457281 No abstract available.
• Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.

  Shiraki M, Shiraki Y, Aoki C, Miura M. Shiraki M, et al. J Bone Miner Res. 2000 Mar;15(3):515-21. doi: 10.1359/jbmr.2000.15.3.515. J Bone Miner Res. 2000. PMID: 10750566 Clinical Trial.