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. 2001 May;22(5):265-8.
doi: 10.1016/s1471-4906(01)01888-9.

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

H Nishimura  1 , T Honjo
Affiliations

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

H Nishimura et al. Trends Immunol. 2001 May.

Abstract

PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The constitutive expression of PD-1 ligands (PD-L1 and PD-L2) on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.

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