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Review
. 2001 May;22(5):269-76.
doi: 10.1016/s1471-4906(01)01896-8.

The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity

R F Wang  1
Affiliations
Review

The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity

R F Wang. Trends Immunol. 2001 May.

Abstract

The identification of tumor antigens has generated a resurgence of interest in immunotherapy for cancer. However, both clinical and animal studies suggest that therapeutic strategies that have mainly focused on the use of CD8+ T cells (and MHC class I-restricted tumor antigens) are not effective in eliminating cancer cells. Recent interest has been directed towards the use of CD4+ T cells in generating antitumor immunity. To this end, the identification of MHC class II-restricted tumor antigens that can stimulate CD4+ T cells might provide opportunities for developing effective cancer vaccines.

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