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Review
. 2001 Apr 28;322(7293):1052-6.
doi: 10.1136/bmj.322.7293.1052.

The complexities of predictive genetic testing

J P Evans  1 , C Skrzynia, W Burke
Affiliations
Review

The complexities of predictive genetic testing

J P Evans et al. BMJ. .
No abstract available

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Figures

Figure 1
Figure 1
Utility in predictive genetic testing
Figure 2
Figure 2
Families' experiences affect their perceptions of utility of predictive genetic testing. The affected woman in family A, whose sisters and mother died of breast cancer, may perceive chemoprevention or prophylactic surgery favourably, and welcome the guidance that predictive genetic testing can provide in making such decisions. Her counterpart (arrowed) in family B may perceive breast cancer to be a less traumatic disease and feel comfortable with routine surveillance, thus lessening the utility of testing for her
Figure 3
Figure 3
Family structure affects perceptions of utility of predictive genetic testing. The woman with four daughters unaffected by breast cancer (family A) may feel that information on risk may be of benefit for their sake, whereas for the woman with no progeny (family B) the utility of such testing declines
See this image and copyright information in PMC

Comment in

References

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    1. Burke W, Petersen G, Lynch P, Botkin J, Daly M, Garber J, et al. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. JAMA. 1997;277:915–919. - PubMed
    1. Khoury MJ, Thrasher JF, Burke W, Gettig EA, Fridinger F, Jackson R. Challenges in communicating genetics: a public health approach. Genetics in Medicine. 2000;2:198–202. - PubMed
    1. Jones M. The genetic report card. New York Times Magazine 2000 11 Jun:80.
    1. Hoff AO, Cote GJ, Gagel RF. Multiple endocrine neoplasias. Annu Rev Physiol. 2000;62:377–411. - PubMed

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