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. 2001 Apr 23;11(8):973-6.
doi: 10.1016/s0960-894x(01)00105-6.

Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists

J T Link  1 , B Sorensen, G Liu, Z Pei, E B Reilly, S Leitza, G Okasinski
Affiliations

Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists

J T Link et al. Bioorg Med Chem Lett. .

Abstract

Diarylsulfide cyclopropylamides were synthesized and evaluated as LFA-1/ICAM-1 interaction antagonists. A substituent pattern was identified which maximized potency and minimized protein binding as exemplified by antagonist 30 (IC50 = 5 nM).

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