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Review
. 2001 May;7(5):541-7.
doi: 10.1038/87865.

The cellular neurobiology of depression

H K Manji  1 , W C Drevets, D S Charney
Affiliations
Review

The cellular neurobiology of depression

H K Manji et al. Nat Med. 2001 May.

Abstract

Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

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