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Review
. 2001 Apr;3(4):323-32.
doi: 10.1016/s1286-4579(01)01386-7.

Is antigen presentation the primary function of HLA-G?

P Le Bouteiller  1 , C Solier
Affiliations
Free article
Review

Is antigen presentation the primary function of HLA-G?

P Le Bouteiller et al. Microbes Infect. 2001 Apr.
Free article

Abstract

Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness.

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